Introduction:
The Department of Animal Husbandry at UP University of Medical Sciences was created in the year 2007 by the
Former Director sir, Dr. (Brig.) T. Prabhakar, UPRIMS & R, Saifai, Etawah and the University (formerly
UP
RIMS &
R) got registered with Committee for the Purpose of Control and Supervision of Experiments on Animals
(CPCSEA)
for experimentation on animals for “Education and Research” as per the MCI regulations, 1999. Later on an
amendment in registration of UP University of Medical Sciences was done in the year 2016 and the University
got
the permission for “Research for Education purpose and breeding for in-house use” of small animals as well
as
large animal (sheep).
The Institutional Animal Ethics Committee (IAEC) has been functioning at UP University of Medical Sciences
from
the year 2007 and the first “SOP for IAEC for experimentations on animals” was prepared in the year 2011.
Due to
several modifications in animal experimentations as well as in animal Ethics, this SOP was revised in the
year
2016. Further, in 2019, the SOP for Animal House activities was prepared and approved by the competent
authority. The approval of SOP for the investigators/ researchers working in animal lab is under process.
Dr. Amita Singh, Veterinary Officer is the In-charge of the Animal Husbandry department and this department
is
working under the Head, Department of Pharmacology, UPUMS since August, 2018.
As the Veterinary care is an essential part of an animal care and use Program. Therefore, the primary focus
of
the veterinarian is to oversee the well-being and clinical care of animals used in research, testing,
teaching,
and production. In the department, an adequate veterinary care program, consists of assessment of animal
well
being and effective management of following:-
- Animal procurement and transportation
- Preventive medicine (including quarantine, animal biosecurity, and surveillance)
- Clinical disease, disability, or related health issues
- Protocol-associated disease, disability, and other sequelae
- Surgery and perioperative care
- Pain and distress
- Anesthesia and analgesia
- Euthanasia.
- Making provisions for the health and welfare of animals.
- Providing advice, instruction, and assistance to investigators on laboratory animal–related matters
and
provide practical support of research programs.
- Ensuring compliance with all the laws, regulations, and guidelines relevant to the
production,
maintenance, and use of laboratory animals and related to management of the animal facility.
Infrastructure:
- The University is registered with CPCSEA (Committee for the Purpose of Control and Supervision of
Experiments on Animals) for “Research for Education purpose & In-house breeding of small and
large
animals (sheep)” - CPCSEA registration no.-1087/GO/ReBi-S/ReBi-L/07/CPCSEA.
- The animal house is well equipped with the cages for rabbits, rats, mice, guinea pigs, dogs and
monkeys.
- O.T. of animal house is well equipped with the operation tables, O.T. light, surgical instruments
etc.
- The department has actively participated in the MCI inspections & CPCSEA inspections held in the
University.
- The SOP for IAEC (prepared in 2011 & revised in 2016), the SOP for Animal House
activities (2019) and the SOP for Investigators/researchers working in animal lab (2022) are
prepared by
the department.
Future Plan:
- Development of Veterinary Diagnostic laboratory (for “surveillance, Diagnosis, Treatment and Control
of
disease”, as per CPCSEA guidelines).
- Approval of new research projects involving animals by IAEC/ CPCSEA.
Services Being Offered:
- Scientific care and management of laboratory animals.
- Providing good animal house facility for lab animals.
- Supplying nutritionally sound and health monitored laboratory animals required for the experiments
or
the research projects of the University.
- Supplying books related to animal experimentation and research in the Central Library.
- Conducting Institutional Animal Ethics Committee (IAEC) meetings time to time to review the progress
of
the experiments/research projects and for discussing the welfare of lab animals.
- Teaching post graduates during animal experimentation.
- Post mortem examination of animals.
- Training technician regarding feeding of different lab animals (rabbits, rats, mice and guinea
pigs),
animal house sanitation, imparting knowledge about the normal physiological parameters of animals,
giving injection to animals, maintenance of animal house records/ stock register related with
feeding,
breeding, mortality, experiments on animals etc.
- Training animal attendants to handle different type of animals, giving knowledge
about
the zoonotic
diseases, the required feed for animals, disinfection of their cages, cleaning of animal house etc.
List of Research Papers Published Recently:
| Sl.No. |
Author |
Year |
Title |
Journal with Vol., No., pages |
| 1 |
Singh Amita, Kumar Raj, Kannaujia SK, Manikrishna, Singh NP |
2021 |
Immunohistochemical studies of blood brain barrier after administration of Abhrak bhasm in
Wistar
rats. |
Int J Sci Res. 10(4): 1-7 |
| 2 |
Singh Amita, Kumar Raj, Kannaujia SK, Manikrishna, Singh NP |
2021 |
Studies on the effects of Abhrak bhasm on haematological and biochemical profile of Wistar rats.
|
Int J Sci Res. 10(5): 12-15 |
| 3 |
Singh Amita, Kumar Raj, Kannaujia SK, Singh NP |
2022 |
The Haematobiochemical and Histopathological studies on the effects of Raj Nirvan Bati (a novel
allovedic drug) in Wistar rats. |
Int J Pharm Pharm Sci.14(2):21-30 |
List of experiments (approved by IAEC) for post graduate students training in the Pharmacology
Department (Status-ongoing):-
[Principal Investigator - Dr. Alok Dixit, Head Department of Pharmacology]
- To demonstrate the analgesic effect of morphine in rat using eddy’s hot plate.
- To demonstrate the anticonvulsant activity of phenytoin against maximal electroshock (MES) induced
convulsions in rats.
- To demonstrate muscle relaxant property of diazepam in mice using rota rod apparatus.
- To learn different routes of administration of drugs in experimental animals.
- To demonstrate the central nervous depressant property of chlorpromazine on locomotion in mice using
actophotometer (activity cage).
- To evaluate the analgesic action of morphine on rats using tail flick method.
- To determine the unknown concentration of given acetylcholine (Ach) by using tissue
rat
ileum.
List of projects involving lab animals in the Microbiology Department (Status-ongoing):-
[Principal Investigator - Dr. Rajesh Kumar Verma, Head Department of Microbiology]
- “Isolation, Culture and Sensitivity test”.
- “Handling of animals for educational purpose”.
List of research projects approved by the IAEC and conducted by the Pharmacology Department in the
past:-
- The Antihyperglycemic effects of concomitant use of ethanolic extract of aloe vera an experimental
study
in rats. [Principal Investigator - Dr. Arvind Kumar Maurya, JR-1]
- A comparative study of antidepressant effect of agomelatine with fluoetine in mice. [Principal
Investigator - Mr. Pankaj Kumar Chaudhary, Demonstrator]
- Phytochemical and Pharmacological evaluation of Cassia glauca & Ficus arnottiana in rats.
[Principal
Investigator - Mr. Vinay Kumar Gupta, Lecturer]
- Comparision of anti-inflammatory efficacy of lercanidipine and Tanacetun parthenium with
indomethacin in
rats. [Principal Investigator - Dr. Neeraj Rajdan, JR-1]
Participation in online trainings / Webinars/ courses, during COVID-19 pandemic:-
| Sl.No. |
Title |
Duration/Date |
| 1 |
“7 days online training on Basic Techniques in Laboratory Animal Care and Management” Organized
by
C.V.Sc., Parabhani, Maharashtra |
02th to 08th September, 2020 |
| 2 |
National webinar on “Biosafety Issues related to COVID-19 Testing and Zoonotic Diseases”
organized
by Dept. of Veterinary Public Health, C.V.Sc., DUVASU, Mathura |
28th September,2020 |
| 3 |
National Webinar entitled “Role of Laboratory Animals in Preclinical Studies”. |
10th October, 2020 |
| 4 |
Online Industrial Training Program conducted by TRICHINOPOLY. Ititled “Use of Laboratory Animals
in
Teaching, Testing and Research”. |
11th October, 2020 |
| 5 |
11 days online training on “Advances in diagnosis and management of ailments in pet animals”
organized by Dept. of Veterinary Surgery and Radiology, C.V.Sc. &A.H., Mhow. (M.P.) |
25th January, 2021 to 04th February, 2021 |
| 6 |
Webinar on “Parasitic Zoonoses- frequently encountered in animals but obscure in humans in
India”
organized by Bihar Veterinary College, Bihar Animal Sciences University, Patna. |
06th July, 2021 |
| 7 |
Continuing Education online course on “Laboratory Animal Management” from Indian Institute of
Science, Bengaluru. |
January to May, 2021 |
| 8 |
Continuing Education online course on “Preclinical Drug Research Regulatory Perspective” from
Indian
Institute of Science, Bengaluru. |
January to May, 2021 |
| 9 |
The Paediatric Covid-19 Management Online Training conducted by Medical Education and Medical
Health
Department of Uttar Pradesh. |
23rd August to 26th August, 2021 |
Training of Staff:
Technician for Animal Operation Room has completed “Laboratory Animal Technician Training Course” on Humane
Care, Scientific Management and Welfare of Laboratory Animals and Basic Animal Techniques, organized at
NLAC,
CSIR-CDRI, Lucknow from December7-18, 2015 in collaboration with National Institute of Welfare (NIAW),
Ministry
of environment, Forest & Climate Change, Government of India.